FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

19871,242 citationsJournal Articlebronze Open Access

Authors

Toru Kino · Fujisawa City Hospital

Hiroshi Hatanaka

Abstract

FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O. The compound suppressed immune responses in vitro and in vivo with mice. This immunosuppressive effect was more potent than that of ciclosporin.

Topics & Keywords

Cancer therapeutics and mechanisms Quinazolinone synthesis and applications Synthesis and Biological Evaluation

Publication Details

Published in: The Journal of Antibiotics

Volume 40, Issue 9, pp. 1249-1255

DOI: 10.7164/antibiotics.40.1249

Field-Weighted Citation Impact: 9.68

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FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.

Authors

Abstract

Topics & Keywords

Publication Details