Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation

201839 citationsJournal Article

Authors

Sensheng Liu · China Three Gorges University

Huan Liu · China Three Gorges University

Haifeng Zhou · China Three Gorges University

Qixing Liu · China Three Gorges University

Jinliang Lv · Humanwell Healthcare Group (China)

Abstract

A novel full atom-economic process for the transformation of alkynes into chiral alcohols by TfOH-catalyzed hydration coupled with Ru-catalyzed tandem asymmetric hydrogenation in TFE under simple conditions has been developed. A range of chiral alcohols was obtained with broad functional group tolerance, good yields, and excellent stereoselectivities.

Topics & Keywords

Asymmetric Hydrogenation and Catalysis Catalysis for Biomass Conversion Catalytic C–H Functionalization Methods

Publication Details

Published in: Organic Letters

Volume 20, Issue 4, pp. 1110-1113

DOI: 10.1021/acs.orglett.8b00034

Field-Weighted Citation Impact: 2.21

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Transformation of Alkynes into Chiral Alcohols via TfOH-Catalyzed Hydration and Ru-Catalyzed Tandem Asymmetric Hydrogenation

Authors

Abstract

Topics & Keywords

Publication Details