Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis

201833 citationsJournal Articlehybrid Open Access

Authors

Lydia Ntari · Alexander Fleming Biomedical Sciences Research Center

Μαρία Σάκκου · Alexander Fleming Biomedical Sciences Research Center

Panagiotis Chouvardas · National and Kapodistrian University of Athens

Iordanis Mourouzis · National and Kapodistrian University of Athens

Alejandro Prados · Alexander Fleming Biomedical Sciences Research Center

Maria C. Denis

Niki Karagianni

Abstract

Comorbidheart valve disease and chronic polyarthritis are efficiently modelled in the Tg197 arthritis model and share common TNF/TNFR1-mediated, mesenchymal cell-specific aetiopathogenic mechanisms.

Topics & Keywords

Viral Infections and Immunology Research Cardiac Valve Diseases and Treatments Rheumatoid Arthritis Research and Therapies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of the Rheumatic Diseases

Volume 77, Issue 6, pp. 926-934

DOI: 10.1136/annrheumdis-2017-212597

Field-Weighted Citation Impact: 3.41