Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

2018286 citationsJournal Articlegold Open Access

Authors

Gaofeng Liang · Henan University of Science and Technology

Shu Kan

Yanliang Zhu · State Key Laboratory of Digital Medical Engineering

Shuying Feng · Henan University of Science and Technology

Wenpo Feng · Henan University of Science and Technology

Shegan Gao · Henan University of Science and Technology

Abstract

Our gene delivery strategy can be adapted to treat a broad spectrum of cancers by expressing proteins on the surface of miRNA-loaded exosomes that recognize specific biomarkers on the tumor cell.

Topics & Keywords

Extracellular vesicles in disease RNA Interference and Gene Delivery MicroRNA in disease regulation

Publication Details

Published in: International Journal of Nanomedicine

Volume Volume 13, pp. 585-599

DOI: 10.2147/ijn.s154458

Field-Weighted Citation Impact: 9.31

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Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

Authors

Abstract

Topics & Keywords

Publication Details