Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma

We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Concurrent treatment was previously reported in the <i>palliative</i> and <i>recurrent</i> setting. This is the first case of concurrent vismodegib and radiation therapy for <i>upfront definitive</i> management. The patient experienced complete response in all treated lesions.