Clinical application of targeted next‐generation sequencing in fetuses with congenital heart defect

201859 citationsJournal Articlebronze Open Access

Authors

Ping Hu · Nanjing Maternity and Child Health Care Hospital

Fengchang Qiao · Nanjing Maternity and Child Health Care Hospital

Yishuang Wang · Nanjing Maternity and Child Health Care Hospital

Lu Meng · Nanjing Maternity and Child Health Care Hospital

Xiaochun Ji · Nanjing Maternity and Child Health Care Hospital

Chengwen Luo · Nanjing Maternity and Child Health Care Hospital

Abstract

Targeted NGS in fetuses with isolated and non-isolated CHD achieved a high diagnostic yield in our cohort, with an acceptable turnaround time for the prenatal setting. Our results have important implications for clinical management and genetic counseling. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.

Topics & Keywords

Tracheal and airway disorders Congenital Heart Disease Studies Congenital heart defects research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Ultrasound in Obstetrics and Gynecology

Volume 52, Issue 2, pp. 205-211

DOI: 10.1002/uog.19042

Field-Weighted Citation Impact: 4.40