Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

2018190 citationsJournal Articlehybrid Open Access

Authors

Tom Seijkens · Ludwig-Maximilians-Universität München

Claudia M. van Tiel · University of Amsterdam

Pascal Kusters · Amsterdam UMC Location University of Amsterdam

Dorothee Atzler · University of Amsterdam

Oliver Soehnlein · Ludwig-Maximilians-Universität München

Barbara Zarzycka · Maastricht University

Suzanne A. B. M. Aarts

Abstract

TRAF-STOPs can overcome the current limitations of long-term CD40 inhibition in atherosclerosis and have the potential to become a future therapeutic for atherosclerosis.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases Cell Adhesion Molecules Research NF-κB Signaling Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of the American College of Cardiology

Volume 71, Issue 5, pp. 527-542

DOI: 10.1016/j.jacc.2017.11.055

Field-Weighted Citation Impact: 8.52