Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

201848 citationsJournal Articlegold Open Access

Authors

Chunwan Lu · Walker (United States)

Dafeng Yang · Walker (United States)

María E. Sabbatini · Augusta University

Aaron H. Colby · Boston University

Mark W. Grinstaff · Boston University

Nicholas H. Oberlies · University of North Carolina at Greensboro

Cedric J. Pearce ·

Abstract

We determined that PDAC cells use H3K4me3 to activate Bcl-x, FLIP and Mcl-1, and H3K9me3 to silence Bak, Bax and Bim to acquire an apoptosis-resistant phenotype. Therefore, selective inhibition of H3K4me3 and H3K9me3 is potentially an effective approach to overcome PDAC cells resistance to gemcitabine.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Epigenetics and DNA Methylation Lung Cancer Research Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Cancer

Volume 18, Issue 1, pp. 149-149

DOI: 10.1186/s12885-018-4061-y

Field-Weighted Citation Impact: 2.74