Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome

2018187 citationsJournal Articlehybrid Open Access

Authors

Tao Ding · Changhai Hospital

Shaofei Wang · Fudan University

Xuyao Zhang · Fudan University

Wenjing Zai · Fudan University

Jiajun Fan · Fudan University

Wei Chen · Fudan University

Qi Bian · Changhai Hospital

Abstract

The results revealed that DHQ possesses kidney protection effects including attenuating urine microalbumin excretion, hyperglycemia and lipid metabolism disorders, and mitigating renal histopathological lesions on DN, and one of the possible renal-protective mechanisms is suppressing ROS and NLRP3 inflammasome.

Topics & Keywords

Inflammasome and immune disorders Heme Oxygenase-1 and Carbon Monoxide Biomarkers in Disease Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Phytomedicine

Volume 41, pp. 45-53

DOI: 10.1016/j.phymed.2018.01.026

Field-Weighted Citation Impact: 6.13