213 New Findings Regarding the Timeline of Microorganisms in Inflatable Penile Prosthesis Infections

Little is known in the literature about the natural history of inflatable penile prosthesis (IPP) infections. We reviewed our multi-institution database of IPP infections to examine for patterns and potential timelines of infection for the various types of organisms seen in culture during salvage or explant surgery. This is a retrospective IRB-approved analysis of 213 patients at 25 institutions who underwent salvage procedure or device explant between 2001 and 2016. Patient data were compiled after extensive review of operative reports, nursing operative data, intraoperative wound cultures, perioperative antibiotics, inpatient notes, consult notes, and follow-up visits. Gram positive, Gram negative, fungal, and anaerobic infections were evaluated to gauge time to salvage or explant surgery. Multiorganism infections and infections with no growth seen in culture were examined as well. Rigorous statistical analysis was performed. Seven isolated anaerobic infections were treated on average 2.6 months after device implantation (range 1-7.5 months, median 2 months). Sixty-two isolated Gram positive infections were treated on average 4.5 months after device implantation (range 2 weeks to 38.5 months, median 2 months). Fourteen isolated fungal infections were treated on average 5.8 months after device implantation (1 month to 27 months, median 3 months). Thirty-nine isolated Gram negative infections were treated on average 6.96 months after device implantation (range 2 weeks to 81 months, median 1.5 months). Twenty-four multiorganism infections were treated on average 5.2 months after device implantation (range two weeks to 27 months). Sixty-seven infections had no growth seen in culture and were treated on average 4 months after device implantation (range two weeks to 58 months, median 1.5 months).