DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma

2018116 citationsJournal Articlebronze Open Access

Authors

Jonathan D. Wasserman · University of Toronto

Nelly Sabbaghian · Jewish General Hospital

Somayyeh Fahiminiya · McGill University Health Centre

Rose Chami · Hospital for Sick Children

Özgür Mete · University of Toronto

Meryl Acker · Hospital for Sick Children

Mona K. Wu ·

Abstract

DICER1 is a driver of pediatric thyroid nodules, and DICER1-mutated PTC may represent a distinct class of low-risk malignancies. Given the prevalence of variants in children, we advocate for inclusion of DICER1 sequencing and gene dosage determination in molecular analysis of pediatric thyroid specimens.

Topics & Keywords

Thyroid Cancer Diagnosis and Treatment Congenital Diaphragmatic Hernia Studies Head and Neck Anomalies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 103, Issue 5, pp. 2009-2015

DOI: 10.1210/jc.2017-02698

Field-Weighted Citation Impact: 8.01