Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

201868 citationsJournal Articlegold Open Access

Authors

Menuka Pallebage‐Gamarallage · University of Oxford

Sean Foxley · Wellcome Centre for Integrative Neuroimaging

Ricarda Menke · University of Oxford

István N. Huszár · Wellcome Centre for Integrative Neuroimaging

Mark Jenkinson · Wellcome Centre for Integrative Neuroimaging

Benjamin C. Tendler · Wellcome Centre for Integrative Neuroimaging

Chaoyue Wang

Abstract

The proposed post mortem whole brain sampling methodology enables the accurate intraindividual study of pathological propagation and comparison with quantitative MRI data, to more fully understand the relationship of imaging signal changes with underlying pathophysiology in ALS.

Topics & Keywords

Amyotrophic Lateral Sclerosis Research Parkinson's Disease Mechanisms and Treatments Neurogenetic and Muscular Disorders Research

Publication Details

Published in: BMC Neuroscience

Volume 19, Issue 1, pp. 11-11

DOI: 10.1186/s12868-018-0416-1

Field-Weighted Citation Impact: 5.61

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Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

Authors

Abstract

Topics & Keywords

Publication Details