Efficacy and Safety of Intermittent Intravenous Outpatient Administration of Levosimendan in Patients With Advanced Heart Failure: The LION-HEART Multicentre Randomised Trial

2018184 citationsJournal Articlegreen Open Access

Authors

Josep Comín‐Colet · Universitat Autònoma de Barcelona

Nicolás Manito · Universitat de Barcelona

Javier Segovia · Hospital Universitario Puerta de Hierro Majadahonda

Juan F. Delgado · Hospital Universitario 12 De Octubre

José Manuel García Pinilla · Hospital Clínico Universitario Virgen de la Victoria

Luís Almenar · Hospital Universitari i Politècnic La Fe

María G. Crespo‐Leiro

Abstract

In this small pilot study, intermittent administration of levosimendan to ambulatory patients with advanced systolic heart failure reduced plasma concentrations of NT-proBNP, worsening of HRQoL and hospitalisation for heart failure. The efficacy and safety of this intervention should be confirmed in larger trials.

Topics & Keywords

Heart Failure Treatment and Management Cardiac pacing and defibrillation studies Cardiac Structural Anomalies and Repair

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: European Journal of Heart Failure

Volume 20, Issue 7, pp. 1128-1136

DOI: 10.1002/ejhf.1145

Field-Weighted Citation Impact: 13.48