Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

2018395 citationsJournal Articlebronze Open Access

Authors

Síle F. Molloy · St George's, University of London

Cecilia Kanyama · Kamuzu Central Hospital

Robert S. Heyderman · University of Liverpool

Angela Loyse · St George's, University of London

Charles Kouanfack · Université de Dschang

Duncan Chanda · University Teaching Hospital

Sayoki Mfinanga

Abstract

One week of amphotericin B plus flucytosine and 2 weeks of fluconazole plus flucytosine were effective as induction therapy for cryptococcal meningitis in resource-limited settings. (ACTA Current Controlled Trials number, ISRCTN45035509 .).

Topics & Keywords

Fungal Infections and Studies Antifungal resistance and susceptibility Nail Diseases and Treatments

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: New England Journal of Medicine

Volume 378, Issue 11, pp. 1004-1017

DOI: 10.1056/nejmoa1710922

Field-Weighted Citation Impact: 30.63