Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

20181,307 citationsJournal Articlebronze Open Access

Authors

Matthew R. Smith · Harvard University

Fred Saad · Centre Hospitalier de l’Université de Montréal

Simon Chowdhury · The King's College

Stéphane Oudard · Centre Pompidou

Boris Hadaschik · Heidelberg University

Julie N. Graff · VA Portland Health Care System

David Olmos

Abstract

Among men with nonmetastatic castration-resistant prostate cancer, metastasis-free survival and time to symptomatic progression were significantly longer with apalutamide than with placebo. (Funded by Janssen Research and Development; SPARTAN ClinicalTrials.gov number, NCT01946204 .).

Topics & Keywords

Prostate Cancer Treatment and Research Cancer, Lipids, and Metabolism Radiopharmaceutical Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 378, Issue 15, pp. 1408-1418

DOI: 10.1056/nejmoa1715546

Field-Weighted Citation Impact: 125.45