Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

201879 citationsJournal Article

Authors

Birgitt Gutbier · Humboldt-Universität zu Berlin

Anne-Kathrin Neuhauß · Humboldt-Universität zu Berlin

Katrin Reppe · Humboldt-Universität zu Berlin

Carolin Ehrler · Humboldt-Universität zu Berlin

Ansgar Santel · Silence Therapeutics (Germany)

Jörg Kaufmann · Silence Therapeutics (Germany)

Markus Scholz

Abstract

These data suggest a central role of angiopoietin-1/-2 in pneumonia-evoked inflammation and permeability. Increased angiopoietin-2 serum levels predicted mortality and length of hospital stay, and angiopoietin-1 may provide a therapeutic target for severe pneumonia.

Topics & Keywords

Lipid metabolism and disorders Inflammatory Biomarkers in Disease Prognosis Inflammation biomarkers and pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 198, Issue 2, pp. 220-231

DOI: 10.1164/rccm.201708-1733oc

Field-Weighted Citation Impact: 6.48