Uric acid as an independent predictor of coronary artery disease in essential hypertension: Data from an 8‐year‐follow‐up study

Summary The role of serum uric acid ( SUA ) in cardiovascular risk prediction remains to be further determined. We assessed the predictive value of SUA for the incidence of coronary artery disease ( CAD ) in 2287 essential hypertensive patients who were followed up for a mean period of 8 years. The distribution of SUA levels at baseline was split by the median (5.2 mg/ dL ) and subjects were classified into those with high and low values. Hypertensives who developed CAD (n = 57) compared to those without CAD at follow‐up (n = 2230) had at baseline higher SUA . In multivariate Cox regression model, among established confounders, high SUA (hazard ratio = 1.216, P = .016) turned out to be independent predictor of CAD . In essential hypertensive patients SUA independently predicts CAD .