Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2

2018155 citationsJournal Articlehybrid Open Access

Authors

Tian Lan · Key Laboratory of Guangdong Province

Changzheng Li · Guangdong Pharmaceutical University

Guizhi Yang · Guangdong Pharmaceutical University

Yue Sun · Guangdong Pharmaceutical University

Lihang Zhuang · Key Laboratory of Guangdong Province

Yitao Ou · Guangdong Pharmaceutical University

Hui Li

Abstract

SphK1 has distinct roles in the activation of KCs and HSCs in liver fibrosis. Mechanistically, SphK1 in KCs mediates CCL2 secretion, and SphK1 in HSCs upregulates CCR2 by downregulation of miR-19b-3p. (Hepatology 2018).

Topics & Keywords

Liver physiology and pathology Sphingolipid Metabolism and Signaling Phagocytosis and Immune Regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 68, Issue 3, pp. 1070-1086

DOI: 10.1002/hep.29885

Field-Weighted Citation Impact: 9.24