Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

2018666 citationsJournal Articlegreen Open Access

Authors

Siamak MahmoudianDehkordi · Duke University

Matthias Arnold · Duke University

Kwangsik Nho · Indiana University – Purdue University Indianapolis

Shahzad Ahmad · Erasmus University Rotterdam

Wei Jia · Shanghai Jiao Tong University

Guoxiang Xie · University of Hawaiʻi at Mānoa

Gregory Louie

Abstract

We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study. These findings warrant further investigation of gut dysbiosis and possible role of gut-liver-brain axis in the pathogenesis of AD.

Topics & Keywords

Drug Transport and Resistance Mechanisms Gut microbiota and health Pharmacogenetics and Drug Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 15, Issue 1, pp. 76-92

DOI: 10.1016/j.jalz.2018.07.217

Field-Weighted Citation Impact: 19.57