Prospective Study of Cancer Genetic Variants: Variation in Rate of Reclassification by Ancestry

201868 citationsJournal Articlebronze Open Access

Authors

Thomas P. Slavin · City of Hope

Lily R. Van Tongeren · City of Hope

Carolyn E. Behrendt

Ilana Solomon · City of Hope

Christina Rybak · City of Hope

Bita Nehoray · City of Hope

Lili Kuzmich · City of Hope

Mariana Niell‐Swiller

Abstract

For nonbenign variants in cancer-related genes, the rates at which reclassifications are issued vary by ancestry in ways that differ between BRCA1/2 and other genes.

Topics & Keywords

BRCA gene mutations in cancer Genomics and Rare Diseases CRISPR and Genetic Engineering

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 110, Issue 10, pp. 1059-1066

DOI: 10.1093/jnci/djy027

Field-Weighted Citation Impact: 4.87