An image‐based model of brain volume biomarker changes in Huntington's disease

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Authors

P. A. Wijeratne · University College London

Alexandra L. Young · University College London

Neil P. Oxtoby · University College London

Razvan Marinescu · University College London

Nicholas C. Firth · University College London

Eileanoir B. Johnson · University College London

Amrita Mohan

Abstract

We used a data-driven method to provide new insight into Huntington's disease progression as well as new power to stage and predict conversion. Our results highlight the potential of disease progression models, such as the event-based model, to provide new insight into Huntington's disease progression and to support fine-grained patient stratification for future precision medicine in Huntington's disease.

Topics & Keywords

Genetic Neurodegenerative Diseases Neurological disorders and treatments Mitochondrial Function and Pathology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Clinical and Translational Neurology

Volume 5, Issue 5, pp. 570-582

DOI: 10.1002/acn3.558

Field-Weighted Citation Impact: 3.13