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<p><span lang="EN-US">To realize the genetic potential of animals, an important role should be taken to prevent the presence of mineral substances in the rations. Because of their lack of revenue in the body of animals the productivity is decreased, the reproductive function is disturbed, there is a disease. there are diseases.</span></p><p><span lang="EN-US">Material for the scientific and economic experiment on the use of mixed ligand complexes of Zinc, Manganese and Cobalt on the milk productivity of high-yielding cows and the exchange of Mangan in their body were Holstein animals, Ukrainian Black- Spotted dairy and Ukrainian Red - Spotted dairy breeds. The trace elements were introduced into feed concentrates, and they into the fodder mix by the method of weight dosing and multi-stage mixing. Balancing of rations of highly productive cows of the 1st control group to norm only Selenium, Kuprum and Iodine, led to a concentration in 1 kg DM (dry matter) of feed mix, mg: Zinc – 32.4; Manganese – 27.8; Cobalt – 0.27; Selenium – 0.3; Copper – 12 and Iodine – 1.1 and the lowest concentration of Mangan in milk and in the body. The cows of the 2nd and 3rd experimental groups were fed with all the trace elements to the norm (for the 2nd experimental group at the expense of zinc sulfates, manganese, cobalt, copper, selenium, Suplex of Selenium and potassium iodide, for the 3rd instead of zinc sulfates, manganese and mixed cobalt compounds were introduced into their ligand complexes). The concentration of trace elements in these groups in 1 kg of DM was, mg: Zinc – 76; Manganese – 76; Cobalt – 0,97; Copper – 12; Selenium – 0.3 and Iodine – 1.1. The concentration of Zinc, Manganese and Cobalt in 1 kg of DM of fodder was reduced by 20% for cows of the 4th experimental group and by 30% for the 5th experimental group.</span></p><p><span lang="EN-US">The results of the conducted searches indicate that the use in feeding of high-yielding cows of various doses of mixed ligand complexes of Zinc, Manganese, and Cobalt on the use of Suplex of Selenium and sulfate copper and potassium iodide in the first 100- days lactation positively affect the growth of their milk production. Animals of experimental groups dominated cows of analogues of the control group, rations of which were scarce on Zinc, Manganese and Cobalt, by average daily yield of natural milk, respectively, by 4.5; 5.8 and 4.0 kg, or 11.63: 14.99 and 10.34%, and these differences were reliable. While the average daily milk yield of cows of the 2nd experimental group exceeded the average daily yield of the 1st control group by 3.8 kg or by 9.82%. In milk of experimental cows, a single increase in the fat content of 0.01–0.09% was also noted. </span></p><p><span lang="EN-US">Carrying out balance research confirmed the data of milk productivity. Thus, in the body of cows of the 3rd, 4th and 5th experimental groups, more Manganese were deposited, respectively by: 540.7; 531.5, and 394.5 mg compared to control and by 367.1, 357.9, and 220.9 mg – in comparison with the 2nd experimental group; in experimental cows of groups 4 and 5, the manganese was deposited less by 9.2 and 146.2 mg in comparison with the 3rd experimental group. With milk in cows of the 1st control group during the day was allocated 20.8 mg of Manganese, and in the 2nd, 3rd, 4th and 5th experimental groups it was allocated more, respectively by 6.7, 9.8, 15.4, and 10.6 mg. Manganese fecal excretion was less in comparison with the 2nd experimental group, in the cows of the 3rd experimental group it was less by 365.9 mg, in the 4<sup>th</sup> group – by 623.3 mg, and in the 5<sup>th</sup> group – by 691.4 mg.</span></p><p><span lang="EN-US">The use of mixed ligand complexes of Zinc, Manganese and Cobalt enhances the milk productivity of high-yielding cows, reduces their need for these elements, improves their digestion and reduces their excretion with feces.</span></p>