Effect of Statin Coadministration on the Risk of Daptomycin-Associated Myopathy

201862 citationsJournal Articlebronze Open Access

Authors

Ryan K Dare · University of Arkansas for Medical Sciences

Chad Tewell · St. Vincent Hospital

Bryan Harris

Patty W. Wright

Sara L. Van Driest

Eric Farber‐Eger · Vanderbilt University Medical Center

George E. Nelson

Thomas R. Talbot

Abstract

Statin coadministration with daptomycin was independently associated with myopathy and rhabdomyolysis. This is the first study to provide strong evidence supporting this association. During coadministration, we recommend twice-weekly CPK monitoring and consideration of withholding statins.

Topics & Keywords

Antimicrobial Resistance in Staphylococcus Biosimilars and Bioanalytical Methods Infective Endocarditis Diagnosis and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 67, Issue 9, pp. 1356-1363

DOI: 10.1093/cid/ciy287

Field-Weighted Citation Impact: 3.89