Microsatellite instability in prostate cancer by PCR or next-generation sequencing

2018111 citationsJournal Articlegold Open Access

Authors

Jennifer A. Hempelmann · University of Washington

Christina M. Lockwood · University of Washington

Eric Q. Konnick · University of Washington

Michael T. Schweizer · University of Washington Medical Center

Emmanuel S. Antonarakis · Johns Hopkins University

Tamara L. Lotan · Johns Hopkins Medicine

Bruce Montgomery

Abstract

We found that the widely used 5-marker MSI-PCR panel has inferior sensitivity when applied to prostate cancer and that NGS testing with an expanded panel of markers performs well. In addition, NGS methods offer advantages over MSI-PCR, including no requirement for matched non-tumor tissue and an automated analysis pipeline with quantitative interpretation of MSI-status.

Topics & Keywords

Genetic factors in colorectal cancer Prostate Cancer Treatment and Research Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal for ImmunoTherapy of Cancer

Volume 6, Issue 1, pp. 29-29

DOI: 10.1186/s40425-018-0341-y

Field-Weighted Citation Impact: 11.97