GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

201886 citationsJournal Articlegreen Open Access

Authors

Kobina Dufu · Global Blood Therapeutics (United States)

Mira Patel · Global Blood Therapeutics (United States)

Donna Oksenberg · Global Blood Therapeutics (United States)

Pedro Cabrales · University of California San Diego

Abstract

GBT440 maintains SS RBC deformability and improves SS blood viscosity by inhibiting HbS polymerization under deoxygenated conditions. These results further support development of GBT440 as a disease-modifying agent in SCD patients.

Topics & Keywords

Hemoglobinopathies and Related Disorders Iron Metabolism and Disorders Erythrocyte Function and Pathophysiology

Publication Details

Published in: Clinical Hemorheology and Microcirculation

Volume 70, Issue 1, pp. 95-105

DOI: 10.3233/ch-170340

Field-Weighted Citation Impact: 4.80

Command Palette

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

Authors

Abstract

Topics & Keywords

Publication Details