Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptors

201850 citationsJournal Articlebronze Open Access

Authors

Natalia M. Kowal · University of Iceland

Philip K. Ahring · University of Sydney

Vivian W. Y. Liao · University of Sydney

Dinesh C Indurti · University of Sydney

Benjamin S. Harvey · Bionomics (Australia)

Susan O’Connor · Bionomics (Australia)

Mary Chebib ·

Abstract

Based on our data, we conclude that galantamine is not a positive allosteric modulator of α7 or α4β2 receptors, which represent the majority of nACh receptors in mammalian brain.

Topics & Keywords

Nicotinic Acetylcholine Receptors Study Cholinesterase and Neurodegenerative Diseases Receptor Mechanisms and Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 175, Issue 14, pp. 2911-2925

DOI: 10.1111/bph.14329

Field-Weighted Citation Impact: 2.67