Burosumab Therapy in Children with X-Linked Hypophosphatemia

2018457 citationsJournal Articlebronze Open Access

Authors

Thomas O. Carpenter · University of Groningen

Michael P. Whyte · University of Groningen

Erik A. Imel · University of Groningen

Annemieke M. Boot · University of Groningen

Wolfgang Högler · University of Groningen

Agnès Linglart · University of Groningen

Raja Padidela ·

Abstract

In children with X-linked hypophosphatemia, treatment with burosumab improved renal tubular phosphate reabsorption, serum phosphorus levels, linear growth, and physical function and reduced pain and the severity of rickets. (Funded by Ultragenyx Pharmaceutical and Kyowa Hakko Kirin; ClinicalTrials.gov number, NCT02163577 ; EudraCT number, 2014-000406-35 ).

Topics & Keywords

Parathyroid Disorders and Treatments Trace Elements in Health Bone and Joint Diseases

Publication Details

Published in: New England Journal of Medicine

Volume 378, Issue 21, pp. 1987-1998

DOI: 10.1056/nejmoa1714641

Field-Weighted Citation Impact: 35.88

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Burosumab Therapy in Children with X-Linked Hypophosphatemia

Authors

Abstract

Topics & Keywords

Publication Details