Sex, amyloid, and <i>APOE</i> ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well‐characterized cohorts

2018272 citationsJournal Articlegreen Open Access

Authors

Rachel F. Buckley · University of Melbourne

Elizabeth C. Mormino · Stanford University

Rebecca E. Amariglio · Harvard University

Michael J Properzi · Center for Pain and the Brain

Jennifer S. Rabin · Massachusetts General Hospital

Yen Ying Lim · University of Melbourne

Kathryn V. Papp

Abstract

Although Aβ did not differ by sex, cognitive decline was greater in females with higher Aβ. Our findings suggest that sex may play a modifying role on risk of Alzheimer's disease-related cognitive decline.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Blood Pressure and Hypertension Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Alzheimer s & Dementia

Volume 14, Issue 9, pp. 1193-1203

DOI: 10.1016/j.jalz.2018.04.010

Field-Weighted Citation Impact: 16.91