Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study

201876 citationsJournal Articlebronze Open Access

Authors

L. Michael Brunt · Washington University in St. Louis

Elena Deych · BioRankings (United States)

Evan D. Kharasch · Washington University in St. Louis

Abstract

In same-day discharge surgery, this pilot study identified a single intraoperative dose of methadone (0.15 mg/kg ideal body weight), which decreased intraoperative and postoperative opioid requirements and postoperative pain, compared with conventional intermittent short-duration opioids, with similar side effects.

Topics & Keywords

Anesthesia and Pain Management Opioid Use Disorder Treatment Pain Management and Opioid Use

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesia & Analgesia

Volume 128, Issue 4, pp. 802-810

DOI: 10.1213/ane.0000000000003464

Field-Weighted Citation Impact: 7.35