Dual Role of Hypoxia-Inducible Factor 1 α in Experimental Pulmonary Tuberculosis: Its Implication as a New Therapeutic Target

201842 citationsJournal Article

Authors

Guillermina Baay-Guzmán · Hospital Infantil de México Federico Gómez

Marco A. Durán-Padilla · Hospital General de México

Jesus Rangel-Santiago · Hospital Infantil de México Federico Gómez

Belén Tirado-Rodríguez · Hospital Infantil de México Federico Gómez

Gabriela Antonio-Andrés · Hospital Infantil de México Federico Gómez

Jorge Barrios‐Payán · Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Abstract

HIF-1α has a dual role in experimental TB. This finding could have therapeutic implications because combined treatment with 2-methoxyestradiol and antibiotics appeared to eliminate mycobacteria more efficiently than conventional chemotherapy during advanced disease.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Respiratory Support and Mechanisms High Altitude and Hypoxia

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Future Microbiology

Volume 13, Issue 7, pp. 785-798

DOI: 10.2217/fmb-2017-0168

Field-Weighted Citation Impact: 1.27