Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization

2018303 citationsJournal Articlegold Open Access

Authors

Mei Jiang · Second Military Medical University

Hairong Wang · Shanghai Pudong New Area Gongli Hospital

Mingming Jin · Second Military Medical University

Xuelian Yang · Shanghai Pudong New Area Gongli Hospital

Hai‐Feng Ji · Second Military Medical University

Yufeng Jiang · Anhui Medical University

Hanwen Zhang

Abstract

Our results suggest that miR-30d-5p-enhanced ADSC-derived exosomes prevent cerebral injury by inhibiting autophagy-mediated microglial polarization to M1.

Topics & Keywords

Extracellular vesicles in disease Neuroinflammation and Neurodegeneration Mechanisms Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 47, Issue 2, pp. 864-878

DOI: 10.1159/000490078

Field-Weighted Citation Impact: 12.43