Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia

201868 citationsJournal Article

Authors

Dian-Shi Wang · Universidad Mayor

Kirusanthy Kaneshwaran · Universidad Mayor

Gang Lei · Universidad Mayor

Fariya Mostafa · Universidad Mayor

Junhui Wang · Universidad Mayor

Irene Lecker · Universidad Mayor

Sinziana Avramescu · Universidad Mayor

Abstract

Dexmedetomidine prevented excessive α5 γ-aminobutyric acid type A receptor function after anesthesia. This novel α2 adrenergic receptor- and brain-derived neurotrophic factor-dependent pathway may be targeted to prevent delirium.

Topics & Keywords

Anesthesia and Sedative Agents Anesthesia and Neurotoxicity Research Cancer, Stress, Anesthesia, and Immune Response

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anesthesiology

Volume 129, Issue 3, pp. 477-489

DOI: 10.1097/aln.0000000000002311

Field-Weighted Citation Impact: 7.20