Gestational changes in buprenorphine exposure: A physiologically‐based pharmacokinetic analysis

201836 citationsJournal Articlebronze Open Access

Authors

Hongfei Zhang · University of Pittsburgh

Hari V. Kalluri · University of Pittsburgh

Jaime R. Bastian · Indivior (United States)

Huijun Chen · Tsinghua University

Ali Mohamed Alshabi · University of Pittsburgh

Steve N. Caritis · University of Pittsburgh

Raman Venkataramanan ·

Abstract

PBPK model-based simulation may be a useful tool to optimize BUP pharmacotherapy during pregnancy, obviating the need to perform pharmacokinetic studies in each trimester and the postpartum period that normally require intensive blood sampling.

Topics & Keywords

Prenatal Substance Exposure Effects Maternal Mental Health During Pregnancy and Postpartum Opioid Use Disorder Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Clinical Pharmacology

Volume 84, Issue 9, pp. 2075-2087

DOI: 10.1111/bcp.13642

Field-Weighted Citation Impact: 6.53