IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

2018167 citationsJournal Articlegold Open Access

Authors

Sungsin Jo · Hanyang University Seoul Hospital

Sung Eun Wang · Hanyang University

Young Lim Lee · Hanyang University Seoul Hospital

Suman Kang · Hanyang University Seoul Hospital

Bitnara Lee · Hanyang University Seoul Hospital

Jinil Han · GeneMatrix (South Korea)

Il‐Hoon Sung ·

Abstract

Our findings indicate that IL-17A regulates osteoblast activity and differentiation via JAK2/STAT3 signaling. They shed light on AS pathogenesis and suggest new rational therapies for clinical AS ankylosis.

Topics & Keywords

Spondyloarthritis Studies and Treatments Psoriasis: Treatment and Pathogenesis Rheumatoid Arthritis Research and Therapies

Publication Details

Published in: Arthritis Research & Therapy

Volume 20, Issue 1, pp. 115-115

DOI: 10.1186/s13075-018-1582-3

Field-Weighted Citation Impact: 14.97

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IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

Authors

Abstract

Topics & Keywords

Publication Details