Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives

2018142 citationseditorialbronze Open Access

Authors

Esben M. Bech · University of Copenhagen

Knud J. Jensen · University of Copenhagen

Abstract

Strategies for half-life extension are often required in the design of new biopharmaceuticals. This Viewpoint focuses on chemical moieties that convey protraction by albumin binding or by self-assembly to form larger structures, with GLP-1 and insulin as examples.

Topics & Keywords

Protein purification and stability Enzyme Catalysis and Immobilization Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: ACS Medicinal Chemistry Letters

Volume 9, Issue 7, pp. 577-580

DOI: 10.1021/acsmedchemlett.8b00226

Field-Weighted Citation Impact: 3.99