Drug Points: Arthralgias and omeparzole

GARTMANN (Swiss Drug Monitoring Centre, write: We describe five cases of arthralgia associated with ome- prazole.In all cases the patients were treated with 20-40 mg omeprazole daily.A 27 year old woman was given omeprazole for a duodenal ulcer that was unresponsive to ranitidine.After 10 days she developed swelling of her fingers, knees, and ankles, with pruritus and erythema over the metacarpal joints.Treatment was stopped and symptoms disappeared within 10 days.