Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures

201856 citationsJournal Article

Authors

Julie Dyall

Elizabeth A. Nelson · University of Virginia

Lisa Evans DeWald

Rajarshi Guha · National Institutes of Health

Abstract

Our study shows the feasibility of identifying pairs of approved drugs that synergistically block Ebola virus infection in cell cultures. We discuss our findings in terms of the theoretic ability of these or alternate combinations to reach therapeutic levels. Future research will assess selected combinations in small-animal models of Ebola virus disease.

Topics & Keywords

Viral Infections and Outbreaks Research Viral Infections and Vectors Disaster Response and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Infectious Diseases

Volume 218, Issue suppl_5, pp. S672-S678

DOI: 10.1093/infdis/jiy304

Field-Weighted Citation Impact: 6.35