Personalized rosuvastatin therapy in problem patients with partial statin intolerance

20184 citationsJournal Articlediamond Open Access

Authors

Aleksandr B. Shek · Interstate Commission for Water Coordination of Central Asia

R. D. Kurbanov · Interstate Commission for Water Coordination of Central Asia

Rano B. Alieva · Interstate Commission for Water Coordination of Central Asia

G J Abdullaeva · Interstate Commission for Water Coordination of Central Asia

Aleksandr Nagay · Interstate Commission for Water Coordination of Central Asia

А. А. Абдуллаев · Academy of Sciences Republic of Uzbekistan

Abstract

In a considerable proportion of ethnic Uzbek patients with CAD and simvastatin intolerance symptoms, serious side effects when switching to a starting dose of rosuvastatin were not observed, and it should be noted that in most cases (72.4%) this phenomenon was observed among the carriers of *3/*3 genotype of the CYP3A5 (6986A> G) gene.

Topics & Keywords

Lipoproteins and Cardiovascular Health Drug Transport and Resistance Mechanisms Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of Medical Science - Atherosclerotic Diseases

Volume 3, Issue 1, pp. 83-89

DOI: 10.5114/amsad.2018.76826

Field-Weighted Citation Impact: 0.47