Effects of Corneal Hydration on Brillouin Microscopy In Vivo

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Authors

Peng Shao · Harvard University

Theo Seiler · Massachusetts General Hospital

Amira M. Eltony · Harvard University

Antoine Ramier · Massachusetts Institute of Technology

Sheldon J. J. Kwok · Harvard University

Giuliano Scarcelli · University of Maryland, College Park

Roberto Pineda ·

Abstract

The ex vivo and in vivo data agree with our theoretical model and support that the effect of corneal hydration on Brillouin frequency comes predominantly from the dependence of the tissue compressibility on the water. Corneal hydration correlates negatively with the Brillouin frequency. During daytime activities, the influence of physiological hydration changes in human corneas is < ± 10 MHz. The sensitivity to hydration may potentially be useful in detecting abnormal hydration change in patients with endothelial disorders.

Topics & Keywords

Corneal surgery and disorders Glaucoma and retinal disorders Ocular Surface and Contact Lens

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Investigative Ophthalmology & Visual Science

Volume 59, Issue 7, pp. 3020-3020

DOI: 10.1167/iovs.18-24228

Field-Weighted Citation Impact: 6.82