Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation

2018118 citationsJournal Articlegold Open Access

Authors

Ran You · Chinese University of Hong Kong

Yuen‐Shan Ho · Hong Kong Polytechnic University

Clara Hiu-Ling Hung · Chinese University of Hong Kong

Yan Liu · Chinese University of Hong Kong

Chun-Xia Huang · Chinese University of Hong Kong

Hei-Nga Chan · Hong Kong Baptist University

See-Lok Ho

Abstract

Intranasal instillation of SiO<sub>2</sub>-NPs results in mood dysfunction and cognitive impairment in young adult mice and causes neurodegeneration-like pathology and synaptic changes via ERK activation.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments Medicinal Plants and Neuroprotection

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Particle and Fibre Toxicology

Volume 15, Issue 1, pp. 28-28

DOI: 10.1186/s12989-018-0263-3

Field-Weighted Citation Impact: 5.17