Assessment of the Validity of Nuclear-Localized Androgen Receptor Splice Variant 7 in Circulating Tumor Cells as a Predictive Biomarker for Castration-Resistant Prostate Cancer

2018238 citationsJournal Articlebronze Open Access

Authors

Howard I. Scher · Memorial Sloan Kettering Cancer Center

Ryon P. Graf · Epic Sciences (United States)

Nicole A. Schreiber · Memorial Sloan Kettering Cancer Center

Anuradha Jayaram · National Health Service

Eric Winquist · Western University

Brigit McLaughlin · Memorial Sloan Kettering Cancer Center

David Lu

Abstract

This study suggests that nuclear-localized AR-V7 protein in circulating tumor cells can identify patients who may live longer with taxane chemotherapy vs ARS inhibitor treatment.

Topics & Keywords

Prostate Cancer Treatment and Research Ubiquitin and proteasome pathways Radiopharmaceutical Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Oncology

Volume 4, Issue 9, pp. 1179-1179

DOI: 10.1001/jamaoncol.2018.1621

Field-Weighted Citation Impact: 26.63