Reappraisal of Reported Genes for Sudden Arrhythmic Death

2018363 citationsJournal Articlegreen Open Access

Authors

S. Mohsen Hosseini · Hospital for Sick Children

Raymond H. Kim · University Health Network

Sharmila Udupa · Toronto General Hospital

Gregory Costain · Hospital for Sick Children

Rebekah Jobling · Hospital for Sick Children

Eriskay Liston · Hospital for Sick Children

Seema M. Jamal

Abstract

Our results contest the clinical validity of all but 1 gene clinically tested and reported to be associated with BrS. These findings warrant a systematic, evidence-based evaluation for reported gene-disease associations before use in patient care.

Topics & Keywords

Cardiac electrophysiology and arrhythmias RNA and protein synthesis mechanisms Ion channel regulation and function

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 138, Issue 12, pp. 1195-1205

DOI: 10.1161/circulationaha.118.035070

Field-Weighted Citation Impact: 29.18