Lung Deposition of the Dry Powder Fixed Combination Beclometasone Dipropionate Plus Formoterol Fumarate Using NEXThaler ^® Device in Healthy Subjects, Asthmatic Patients, and COPD Patients

The fixed extrafine dry powder combination BDP/FF (100/6 μg) administered through the DPI NEXThaler^® achieved similar intrapulmonary deposition in healthy subjects, in asthmatic patients, and COPD patients (approximately 55% of emitted dose) irrespective of the underlying lung disease with a negligible amount of exhaled particles. The study showed high reliability of the device, reproducible dosing, and distribution throughout the lungs. The results supported the concept of efficient delivery of the combination to the target pulmonary regions, thanks to the extrafine formulation. FEV₁ profile confirmed a relevant pharmacodynamic effect of the product.