The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation

2018199 citationsJournal Articlegold Open Access

Authors

Zengli Zhang · Air Force Medical University

Pei Qin · Xi’an Children’s Hospital

Youliang Deng · Air Force Medical University

Zhi Ma · First Affiliated Hospital of Xi'an Jiaotong University

Hang Guo · The Military General Hospital of Beijing PLA

Haiyun Guo · Air Force Medical University

Yushu Hou

Abstract

Microglial GPR30 exerts acute neuroprotective effects by inhibiting TLR4-mediated microglial inflammation, which indicates that GPR30 may be a potential target for the treatment of ischemic stroke.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Menopause: Health Impacts and Treatments Estrogen and related hormone effects

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Neuroinflammation

Volume 15, Issue 1, pp. 206-206

DOI: 10.1186/s12974-018-1246-x

Field-Weighted Citation Impact: 9.68