Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression

201850 citationsJournal Articlegold Open Access

Authors

Chuying Wang · University of Miami

Feng Bai · University of Miami

Li-han Zhang · University of Miami

Alexandria Scott · University of Miami

Enxiao Li · First Affiliated Hospital of Xi'an Jiaotong University

Xin‐Hai Pei · University of Miami

Abstract

This study reveals for the first time that estrogen promotes BRCA1-deficient tumor initiation and progression by stimulation of cell proliferation and activation of EMT, which are dependent on AKT activation and independent of ER.

Topics & Keywords

BRCA gene mutations in cancer Genetic factors in colorectal cancer Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Breast Cancer Research

Volume 20, Issue 1, pp. 74-74

DOI: 10.1186/s13058-018-0996-9

Field-Weighted Citation Impact: 4.88