Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the In Vitro Integrity of T Cells from Cancer Patients

201860 citationsJournal Articlebronze Open Access

Authors

Masato Kobayashi · The University of Texas Southwestern Medical Center

Jin-Sung Chung · The University of Texas Southwestern Medical Center

Muhammad Shaalan Beg · The University of Texas Southwestern Medical Center

Yull Arriaga · The University of Texas Southwestern Medical Center

Udit Verma · The University of Texas Southwestern Medical Center

Kevin D. Courtney · The University of Texas Southwestern Medical Center

Abstract

Blocking DC-HIL function is a potentially useful treatment for at least colorectal cancer with high blood levels of DC-HIL+ MDSCs.See related commentary by Colombo, p. 453.

Topics & Keywords

Immune cells in cancer Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 25, Issue 2, pp. 828-838

DOI: 10.1158/1078-0432.ccr-18-0330

Field-Weighted Citation Impact: 2.49

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Blocking Monocytic Myeloid-Derived Suppressor Cell Function via Anti-DC-HIL/GPNMB Antibody Restores the <i>In Vitro</i> Integrity of T Cells from Cancer Patients

Authors

Abstract

Topics & Keywords

UN Sustainable Development Goals

Publication Details