Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

201899 citationsJournal Articlebronze Open Access

Authors

Sandeep B. Shelar · University of Alabama at Birmingham

Eun‐Hee Shim · University of Alabama at Birmingham

Garrett J. Brinkley · University of Alabama at Birmingham

Anirban Kundu · University of Alabama at Birmingham

Francesca Carobbio · University of Alabama at Birmingham

Tyler Poston · University of Alabama at Birmingham

Jubilee Tan

Abstract

Collectively, our studies provide biochemical and mechanistic insight into the biology of this small molecule and provide new opportunities for treating L-2-HG-driven kidney cancers.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Epigenetics and DNA Methylation Renal cell carcinoma treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 24, Issue 24, pp. 6433-6446

DOI: 10.1158/1078-0432.ccr-18-1727

Field-Weighted Citation Impact: 2.38