Global DNA hypomethylation in breast carcinoma

1999186 citationsJournal Article

Authors

Jorge Soares · Instituto Português de Oncologia Francisco Gentil

António E. Pinto · Instituto Português de Oncologia Francisco Gentil

Celso Cunha · Instituto Português de Oncologia Francisco Gentil

Saudade Andr� · Instituto Português de Oncologia Francisco Gentil

Isabel Bar�o · Instituto Português de Oncologia Francisco Gentil

J. Meneses Sousa · Instituto Português de Oncologia Francisco Gentil

Abstract

The current shows that DNA hypomethylation is increased in breast carcinomas, playing a potentially important role in tumor development. These findings also suggest that DNA methylation status may be a biologic marker with prognostic significance in this group of neoplasms.

Topics & Keywords

Epigenetics and DNA Methylation Cancer Genomics and Diagnostics Genetic Syndromes and Imprinting

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer

Volume 85, Issue 1, pp. 112-118

DOI: 10.1002/(sici)1097-0142(19990101)85:1<112::aid-cncr16>3.0.co;2-t

Field-Weighted Citation Impact: 2.30