Targeting myeloid-derived suppressor cells using all-trans retinoic acid in melanoma patients treated with Ipilimumab

2018190 citationsJournal Articlehybrid Open Access

Authors

Richard P. Tobin · University of Colorado Denver

Kimberly R. Jordan · University of Colorado Anschutz Medical Campus

William A. Robinson · University of Colorado Denver

Dana M. Davis · University of Colorado Anschutz Medical Campus

Virginia F. Borges · University of Colorado Cancer Center

René González · University of Colorado Anschutz Medical Campus

Karl D. Lewis

Abstract

These results illustrate the importance of MDSCs in immunotherapy resistance and provide evidence that targeting MDSCs in cancer patients may augment immunotherapeutic approaches.

Topics & Keywords

Immune cells in cancer Immunotherapy and Immune Responses Chemokine receptors and signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: International Immunopharmacology

Volume 63, pp. 282-291

DOI: 10.1016/j.intimp.2018.08.007

Field-Weighted Citation Impact: 7.74