Clinical translation of immunoliposomes for cancer therapy: recent perspectives

201871 citationsReview

Authors

Di Wang · Jilin University

Yating Sun · Jilin University

Yange Liu · Jilin University

Fanchao Meng · Jilin University

Robert J. Lee · Jilin University

Abstract

Ab: antibody; ADCs: antibody-drug conjugates; API: active pharmaceutical ingredient; ADCC: antibody-dependent cellular cytotoxicity; CR: complete remission; cGMP: current good manufacturing practice; DSPE: distearoyl phosphatidylethanolamine; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; EPR: enhanced permeability and retention; Fc: fragment crystalline; Tf: transferrin; HACA: human-anti-chimeric antibody; HAHA: human-anti-human antibody; HAMA: human-anti-mouse antibody; HER2: human epidermal growth factor 2; IL: immunoliposome; LNPs: lipid nanoparticles; MRI: magnetic resonance imaging; MTD: maximum tolerated dose; PEG: polyethylene glycol; PET: positron emission tomography; PR: partial response; PSMA: prostate-specific membrane antigen; scFv: single-chain variable fragment; SPECT: single photon emission computed tomography; TTR: transthyretin.

Topics & Keywords

Nanoparticle-Based Drug Delivery RNA Interference and Gene Delivery Monoclonal and Polyclonal Antibodies Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Expert Opinion on Drug Delivery

Volume 15, Issue 9, pp. 893-903

DOI: 10.1080/17425247.2018.1517747

Field-Weighted Citation Impact: 2.45